High Fat Diet Impairs Muscle Health
High-Fat Diet Impairs Muscle Health
Before Impacting Function
Skeletal muscle plays a critical role in regulating blood sugar
levels in the body. But few studies have comprehensively
examined how obesity caused by a high-fat diet affects the
health of muscle in adolescents who are pre-diabetic.
In a new study published in the scientific journal PLoS ONE, a team
of McMaster University researchers report that the health of young
adult muscle declines during the pre-diabetic state, which is when
blood sugar levels are higher than normal but lower than during type
2 diabetes. The researchers found that during this period significant
impairments occur in the muscle, even though it appears to be
functioning normally.
"Based on the way the muscles performed, you would think that
they're still healthy. But the fact is the muscle is not healthy. It's
undergone a lot of pathological changes."
The study was conducted by a team of researchers at McMaster
and York universities to examine how a high-fat diet, leading to
obesity, affected the form and function of skeletal muscle. The
researchers found the high-fat diet resulted in insulin resistance,
large increases in fat mass and weight gain. But it also led to
initial adaptations in the muscle.
"What our results tell us is that, initially, skeletal muscle appears to
respond positively to the high-fat diet. By changing the size or type
of its muscle fibres, the muscle adapts to the high-fat diet by saying
'Let's burn more of this fuel,' " the researchers explained.
"But with continued high-fat feeding, we're giving the muscle more
fuel than it can handle. So, even though it has made these initial,
positive changes, continued high-fat feeding is more than the
muscle can cope with. That's when a downward spiral starts."
The researchers also discovered that not all muscles responded
in the same way to obesity. Some adapted by changing their fibre
type, while others altered the size of their fibres. But, in all cases
analyzed, a high-fat diet decreased the ability of skeletal muscle
to use fat or glucose as fuel.
When the researchers looked at function, and examined the
maximum effort the muscles could generate, they discovered no
difference between the high-fat diet group and the control group
which was eating a diet significantly lower in fat. However, if the
muscles were fatigued and then were required to work, the
high-fat diet group didn't recover as quickly as the control group.
"What this suggests is that the muscle is trying to maintain function
despite all the negative changes that have resulted. When we stress
the muscle by fatiguing it, there are some hints toward functional
impairment, but overall the muscle has coped well, functionally."
The authors concluded that early therapeutic interventions in obese,
pre-diabetic youth are needed prior to significant long-term effects
on the growth and function of their muscles. If left untreated,
approximately 25 per cent of people with pre-diabetes will
progress to diabetes within three to five years.
Interested in Learning More About Effective Nutritional
Fat Burning Supplemention?
View Natural Weight Loss Supplement
Before Impacting Function
Skeletal muscle plays a critical role in regulating blood sugar
levels in the body. But few studies have comprehensively
examined how obesity caused by a high-fat diet affects the
health of muscle in adolescents who are pre-diabetic.
In a new study published in the scientific journal PLoS ONE, a team
of McMaster University researchers report that the health of young
adult muscle declines during the pre-diabetic state, which is when
blood sugar levels are higher than normal but lower than during type
2 diabetes. The researchers found that during this period significant
impairments occur in the muscle, even though it appears to be
functioning normally.
"Based on the way the muscles performed, you would think that
they're still healthy. But the fact is the muscle is not healthy. It's
undergone a lot of pathological changes."
The study was conducted by a team of researchers at McMaster
and York universities to examine how a high-fat diet, leading to
obesity, affected the form and function of skeletal muscle. The
researchers found the high-fat diet resulted in insulin resistance,
large increases in fat mass and weight gain. But it also led to
initial adaptations in the muscle.
"What our results tell us is that, initially, skeletal muscle appears to
respond positively to the high-fat diet. By changing the size or type
of its muscle fibres, the muscle adapts to the high-fat diet by saying
'Let's burn more of this fuel,' " the researchers explained.
"But with continued high-fat feeding, we're giving the muscle more
fuel than it can handle. So, even though it has made these initial,
positive changes, continued high-fat feeding is more than the
muscle can cope with. That's when a downward spiral starts."
The researchers also discovered that not all muscles responded
in the same way to obesity. Some adapted by changing their fibre
type, while others altered the size of their fibres. But, in all cases
analyzed, a high-fat diet decreased the ability of skeletal muscle
to use fat or glucose as fuel.
When the researchers looked at function, and examined the
maximum effort the muscles could generate, they discovered no
difference between the high-fat diet group and the control group
which was eating a diet significantly lower in fat. However, if the
muscles were fatigued and then were required to work, the
high-fat diet group didn't recover as quickly as the control group.
"What this suggests is that the muscle is trying to maintain function
despite all the negative changes that have resulted. When we stress
the muscle by fatiguing it, there are some hints toward functional
impairment, but overall the muscle has coped well, functionally."
The authors concluded that early therapeutic interventions in obese,
pre-diabetic youth are needed prior to significant long-term effects
on the growth and function of their muscles. If left untreated,
approximately 25 per cent of people with pre-diabetes will
progress to diabetes within three to five years.
Interested in Learning More About Effective Nutritional
Fat Burning Supplemention?
View Natural Weight Loss Supplement
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